The thresholds of toxicological concern (TTCs) define limit values for substances of
unknown toxicity below which dietary intake is considered to be of no concern to human
health. The TTC concept has already been used for risk assessment of eg food
contaminants or flavoring substances and is in discussion to be applied to other classes of
compounds such as cosmetic ingredients, household products, non-relevant metabolites in
drinking water, and impurities in pharmaceuticals. The present publication aimed to evaluate …