Evaluation of neural regulation and microglial responses to brain injury in larval zebrafish exposed to perfluorooctane sulfonate
Background: Per-and polyfluoroalkyl substances (PFAS) are biopersistent, global pollutants.
Although some in vitro and epidemiological studies have explored the neurotoxic potential
of perfluorooctane sulfonate (PFOS), a prevalent PFAS congener, it is unknown how
developmental PFOS exposure affects neuronal signaling, microglia development, and
microglial–neuron communication. Objectives: We sought to determine the extent to which
PFOS exposure disrupts brain health, neuronal activity, and microglia–neuron …
Although some in vitro and epidemiological studies have explored the neurotoxic potential
of perfluorooctane sulfonate (PFOS), a prevalent PFAS congener, it is unknown how
developmental PFOS exposure affects neuronal signaling, microglia development, and
microglial–neuron communication. Objectives: We sought to determine the extent to which
PFOS exposure disrupts brain health, neuronal activity, and microglia–neuron …
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