Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt's lymphoma
t (8; 14) translocation is the hallmark of Burkitt's lymphoma and results in c-MYC
deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to
the Ig switch regions on chromosome 14. Although the promoter of c-MYC has been
investigated for its mechanism of fragility, little is known about other c-MYC breakpoint
regions. We have analyzed the translocation break points at the exon 1/intron 1 of c-MYC
locus from patients with Burkitt's lymphoma. Results showed that the breakpoint region …
deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to
the Ig switch regions on chromosome 14. Although the promoter of c-MYC has been
investigated for its mechanism of fragility, little is known about other c-MYC breakpoint
regions. We have analyzed the translocation break points at the exon 1/intron 1 of c-MYC
locus from patients with Burkitt's lymphoma. Results showed that the breakpoint region …
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