[PDF][PDF] Evaluation of selected natural compounds for cancer stem cells targeted anti-cancer activity: a molecular docking study
K Mayan, SR Samarakoon… - European Journal of …, 2016 - researchgate.net
European Journal of Medicinal Plants, 2016•researchgate.net
ABSTRACT Aims: Cancer stem cells (CSCs) play significant roles in tumor initiation, relapse,
angiogenesis, metastasis and therapy. Collectively Wnt, Notch, and Hedgehog are major
pathways that have been linked to the drug resistance of CSCs. Eliminating CSCs has been
suggested as a promising approach to cure cancer. Aim of the present study is screening of
selected natural compounds for inhibitors of Wnt, and Hedgehog pathways that have been
linked to the drug resistance of cancer stem cells (CSCs) by in silico molecular docking …
angiogenesis, metastasis and therapy. Collectively Wnt, Notch, and Hedgehog are major
pathways that have been linked to the drug resistance of CSCs. Eliminating CSCs has been
suggested as a promising approach to cure cancer. Aim of the present study is screening of
selected natural compounds for inhibitors of Wnt, and Hedgehog pathways that have been
linked to the drug resistance of cancer stem cells (CSCs) by in silico molecular docking …
Abstract
Aims: Cancer stem cells (CSCs) play significant roles in tumor initiation, relapse, angiogenesis, metastasis and therapy. Collectively Wnt, Notch, and Hedgehog are major pathways that have been linked to the drug resistance of CSCs. Eliminating CSCs has been suggested as a promising approach to cure cancer. Aim of the present study is screening of selected natural compounds for inhibitors of Wnt, and Hedgehog pathways that have been linked to the drug resistance of cancer stem cells (CSCs) by in silico molecular docking analysis. Place and Duration of Study: At the Institute of Biochemistry, Molecular Biology and
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