The TB Vaccine Cluster project funded by the EU Fifth Framework programme aims to
provide novel vaccines against tuberculosis that are suitable for evaluation in humans. This
paper describes the studies of the protective efficacy of vaccines in a guinea pig aerosol-
infection model of primary tuberculosis. The objective was to conduct comparative
evaluations of vaccines that had previously demonstrated efficacy in other animal models.
Groups of 6 guinea pigs were immunized with vaccines provided by the relevant EU Vaccine …