The unique morphological structural patterns of palatal rugae has long been an interesting anatomical structure studied by researchers from various discipline mainly in the fields of Anthropology, comparative Anatomy, Genetics, Forensic Odontology, Prosthodontics and Orthodontics, so as to evaluate its usefulness. This study aimed at evaluating the palatal rugae patterns of basic medical students of University of Port-Harcourt. A total number of 140 volunteers, 70 males and 70 females within the age range18-35 years were recruited for this study. After obtaining consent from the volunteers, maxillary dental casts were made and interpretation of the rugae pattern was done. Thetotal number, length, shape and unification of the palatal rugae patterns were analysed for the right and left side of the palate. This study showed that each individual has a different and unique palatal rugae pattern. The predominant patterns of palatalrugae were wavy and curve patterns followed by straight. This study revealed that the females had slightly more number of rugae which is insignificant in proportion with percentage value of (50.0%) than the male with percentage value of (49.9%). The wavy pattern of rugae was higher in females than males while the males had more curve pattern than the females. There was an insignificant (P> 0.05) gender differences proportionality in the total number of palatal rugae, shape and length of rugaeamongst male and female students. There was insignificant difference in total number of unification of rugae between males and females, with males presenting more diverging pattern than females while females had more converging pattern than males. Chi-sqaure analysis however revealed insignificant association in the distributionand combination patterns of palatal rugae amongst males and females. Our findings concluded that the palatal rugae patterns of an individual are uniquely structured and specie specific. There was no similarity in the rugae patterns of males and females which provides clear evidence of rugae patterns being highly individualistic.