[HTML][HTML] Evasion of cell senescence leads to medulloblastoma progression
L Tamayo-Orrego, CL Wu, N Bouchard, A Khedher… - Cell reports, 2016 - cell.com
How brain tumors progress from precancerous lesions to advanced cancers is not well
understood. Using Ptch1+/− mice to study medulloblastoma progression, we found that
Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell
senescence in preneoplasia. In contrast, advanced tumors have evaded senescence.
Remarkably, we discovered that the majority of advanced medulloblastomas display either
spontaneous, somatic p53 mutations or Cdkn2a locus inactivation. Consistent with …
understood. Using Ptch1+/− mice to study medulloblastoma progression, we found that
Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell
senescence in preneoplasia. In contrast, advanced tumors have evaded senescence.
Remarkably, we discovered that the majority of advanced medulloblastomas display either
spontaneous, somatic p53 mutations or Cdkn2a locus inactivation. Consistent with …
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