Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population
The complex imprinted GNAS locus which encodes G-alpha subunit (Gαs) is involved in a
number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by
Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This
study was designed to evaluate the association between single nucleotide polymorphisms
(SNPs) present in GNAS locus and susceptibility to malaria. In this case control study,
individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) …
number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by
Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This
study was designed to evaluate the association between single nucleotide polymorphisms
(SNPs) present in GNAS locus and susceptibility to malaria. In this case control study,
individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) …
Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population.
HG Himanshu Gupta, SC Sakharwade… - 2013 - cabidigitallibrary.org
The complex imprinted GNAS locus which encodes G-alpha subunit (Gαs) is involved in a
number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by
Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This
study was designed to evaluate the association between single nucleotide polymorphisms
(SNPs) present in GNAS locus and susceptibility to malaria. In this case control study,
individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) …
number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by
Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This
study was designed to evaluate the association between single nucleotide polymorphisms
(SNPs) present in GNAS locus and susceptibility to malaria. In this case control study,
individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) …
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