Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats
I Komsuoglu-Celikyurt, SS Gocmez, O Mutlu, N Gacar… - Life sciences, 2011 - Elsevier
Life sciences, 2011•Elsevier
AIMS: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal
nitric oxide synthase (nNOS) inhibitor, and [1H-[1, 2, 4]-oxadiazole [4, 3a]-quinoxaline-1-
one](ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on
working and reference memory and emotional learning was investigated in rats. MAIN
METHODS: The effects were assessed in the three-panel runway and step-down passive
avoidance task, respectively. KEY FINDINGS: 3-Br 7-NI (5, 10, and 20mg/kg) and ODQ (5 …
nitric oxide synthase (nNOS) inhibitor, and [1H-[1, 2, 4]-oxadiazole [4, 3a]-quinoxaline-1-
one](ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on
working and reference memory and emotional learning was investigated in rats. MAIN
METHODS: The effects were assessed in the three-panel runway and step-down passive
avoidance task, respectively. KEY FINDINGS: 3-Br 7-NI (5, 10, and 20mg/kg) and ODQ (5 …
AIMS
The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on working and reference memory and emotional learning was investigated in rats.
MAIN METHODS
The effects were assessed in the three-panel runway and step-down passive avoidance task, respectively.
KEY FINDINGS
3-Br 7-NI (5, 10, and 20mg/kg) and ODQ (5, 10, and 20mg/kg) significantly increased the number of errors and latency of both working and reference memory performance of rats and impaired retention for the passive avoidance task. The effect of 3-Br 7-NI was reversed by l-arginine (250mg/kg).
SIGNIFICANCE
Findings of the study supported the hypothesis that nNOS inhibition disrupts reference and working memory processes in terms of an impairment in the strategies used for solving learning tasks, and, according to these results, nNOS-sGC may be required for emotional learning and both reference and working memory.
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