Evidence of small-fiber neuropathy (SFN) in two patients with unexplained genital sensory loss and sensory urinary cystopathy
MA AbdelRazek, B Chwalisz, AL Oaklander… - Journal of the …, 2017 - Elsevier
The term small-fiber neuropathy (SFN) refers to the type of polyneuropathies that
preferentially damage the small unmyelinated and thinly myelinated sensory or autonomic
neurons [1]. Skin biopsy to determine the epidermal nerve-fiber density (ENFD) is the most
definitive method in the diagnosis of SFN, but autonomic function testing can also be useful
[2]. Importantly, electromyography and surface nerve-conduction studies (EMG/NCS) do not
capture the small scattered action potentials of small fibers, and thus are insensitive to small …
preferentially damage the small unmyelinated and thinly myelinated sensory or autonomic
neurons [1]. Skin biopsy to determine the epidermal nerve-fiber density (ENFD) is the most
definitive method in the diagnosis of SFN, but autonomic function testing can also be useful
[2]. Importantly, electromyography and surface nerve-conduction studies (EMG/NCS) do not
capture the small scattered action potentials of small fibers, and thus are insensitive to small …
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