Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands
Y Sun, K Senger, TK Baginski, A Mazloom… - Journal of Biological …, 2012 - ASBMB
Paired immunoglobulin-like receptor (PILR) α is an inhibitory receptor that recognizes
several ligands, including mouse CD99, PILR-associating neural protein, and Herpes
simplex virus-1 glycoprotein B. The physiological function (s) of interactions between PILRα
and its cellular ligands are not well understood, as are the molecular determinants of
PILRα/ligand interactions. To address these uncertainties, we sought to identify additional
PILRα ligands and further define the molecular basis for PILRα/ligand interactions. Here, we …
several ligands, including mouse CD99, PILR-associating neural protein, and Herpes
simplex virus-1 glycoprotein B. The physiological function (s) of interactions between PILRα
and its cellular ligands are not well understood, as are the molecular determinants of
PILRα/ligand interactions. To address these uncertainties, we sought to identify additional
PILRα ligands and further define the molecular basis for PILRα/ligand interactions. Here, we …