Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze
the transamination reactions between amino acid donor and keto acid acceptor substrates.
Modern AT enzymes constitute∼ 2% of all classified enzymatic activities, play central roles
in nitrogen metabolism, and generate multitude of primary and secondary metabolites. ATs
likely diverged into four distinct AT classes before the appearance of the last universal
common ancestor and further expanded to a large and diverse enzyme family. Although the …