[HTML][HTML] Ex vivo perfusion induces a time-and perfusate-dependent molecular repair response in explanted porcine lungs
P Dromparis, NS Aboelnazar, S Wagner… - American Journal of …, 2019 - Elsevier
Ex vivo lung perfusion (EVLP) shows promise in ameliorating pretransplant acute lung injury
(ALI) and expanding the donor organ pool, but the mechanisms of ex vivo repair remain
poorly understood. We aimed to assess the utility of gene expression for characterizing ALI
during EVLP. One hundred sixty-nine porcine lung samples were collected in vivo (n= 25),
after 0 (n= 11) and 12 (n= 11) hours of cold static preservation (CSP), and after 0 (n= 57), 6
(n= 8), and 12 (n= 57) hours of EVLP, utilizing various ventilation and perfusate strategies …
(ALI) and expanding the donor organ pool, but the mechanisms of ex vivo repair remain
poorly understood. We aimed to assess the utility of gene expression for characterizing ALI
during EVLP. One hundred sixty-nine porcine lung samples were collected in vivo (n= 25),
after 0 (n= 11) and 12 (n= 11) hours of cold static preservation (CSP), and after 0 (n= 57), 6
(n= 8), and 12 (n= 57) hours of EVLP, utilizing various ventilation and perfusate strategies …
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