Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents
C Benyahia, G Ozen, N Orie, A Ledwozyw… - Prostaglandins & other …, 2015 - Elsevier
Abstract Prostacyclin (PGI 2) mimetics (iloprost, treprostinil) are potent vasodilators (primarily
via IP-receptor activation) and major therapeutic interventions for pulmonary hypertension
(PH). Increased plasma levels of endothelin (ET-1), thromboxane (TxA 2) and
catecholamines have been demonstrated from patients with PH. In this study, we aimed to
compare relaxant effects of iloprost and treprostinil on human (HPA) and rat pulmonary
arteries precontracted with either ET-1, thromboxane (U46619) or an α-adrenergic receptor …
via IP-receptor activation) and major therapeutic interventions for pulmonary hypertension
(PH). Increased plasma levels of endothelin (ET-1), thromboxane (TxA 2) and
catecholamines have been demonstrated from patients with PH. In this study, we aimed to
compare relaxant effects of iloprost and treprostinil on human (HPA) and rat pulmonary
arteries precontracted with either ET-1, thromboxane (U46619) or an α-adrenergic receptor …
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