Do routes with lower doses of air pollution exist in real-world bicycling networks, and do bicyclists actually use those routes? Low-pollution-dose alternative routes for a sample of urban cycling trips were modeled and compared with shortest paths. Bicyclists’ actual route choices on the same trips were observed with the use of GPS data and compared with the low-dose and shortest paths alternatives. With use of past studies of pollution exposure levels and simplified ventilation rates, link-inhaled doses of air pollution were estimated. Findings suggest that a majority of trips have lower-dose alternatives to the shortest path, with a 12% average dose reduction. Cyclists tend to choose routes with pollution concentrations between those of shortest paths and minimum-dose routes, but they also travel considerably farther, leading to total inhaled doses that are higher than on either alternative route. People’s seeming avoidance of nontraffic factors such as hills, excess turns, and difficult intersections leads to longer than optimal detours from a pollution avoidance perspective. Bike paths and bike boulevards (traffic-calmed streets with bicycle priority), as well as denser street grids, appear to provide effective low-pollution alternatives, although such routes tend to encourage excess detours that can add to total inhaled dose. Bike lanes can draw cyclists onto more polluted routes in some circumstances, with poor pollution inhalation outcomes. Overall, excess doses did seem to be a common problem for this sample of cyclists on a real-world network. The study’s findings support policies that provide dense networks of attractive facilities that encourage cyclists to choose direct, lower-pollution routes.