BACKGROUND: Leukotrienes (LTs) are potent proinflammatory lipid mediators with key
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes),
released from macrophages and dendritic cells (DCs), have become increasingly
appreciated as messengers in immunity. OBJECTIVE: We investigated whether exosomes
from human macrophages, DCs, and plasma contain enzymes for LT biosynthesis and
studied potential roles for exosomes in transcellular LT metabolism and granulocyte …