Expansion of human mesenchymal stem cells in fibrous bed bioreactor
Expansion of human mesenchymal stem cells (hMSCs) in bioreactor while preserving their
innate properties is important in translation of hMSC-based therapy to clinical applications.
The present study investigates the feasibility of hMSC expansion in a 2.5 L CelliGen® 310
Bioreactor packed with Fibra-Cel® disks. After 9 days of expansion, a 9.2-fold increase in
cell number with the population doubling (PD) time of 2.8 days (67.2 h) was achieved and
that the specific glucose consumption and lactate production were measured to be 12.48 …
innate properties is important in translation of hMSC-based therapy to clinical applications.
The present study investigates the feasibility of hMSC expansion in a 2.5 L CelliGen® 310
Bioreactor packed with Fibra-Cel® disks. After 9 days of expansion, a 9.2-fold increase in
cell number with the population doubling (PD) time of 2.8 days (67.2 h) was achieved and
that the specific glucose consumption and lactate production were measured to be 12.48 …
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