Nanofluids are being considered as an efficient heat transfer fluid in various thermal applications. In this work, an experimental study was conducted on TiO₂ nanoparticle mixed with R600a as the working fluid. TiO₂-R600a nano-refrigerant was used in a domestic refrigerator with little system reconstruction. The refrigerator performance was then investigated using test parameters including: Pull down test, specific compressor work-input, refrigeration effect and coefficient of performance (COP) using steady state analysis. The results indicate that TiO₂-R600a nano-refrigerant works efficiently and safely in the refrigerator and the performance was better than the pure R600a system. Overall, 0.1g TiO₂ in 40g R600a nano-refrigerant mixture had the highest refrigeration effect and COP and gave the least specific compressor work-input within the test rig.