The velocity field in the central sagittal plane of an idealized representation of the human oropharynx (HOP) during steady inspiration, simulating oral inhalation through an inhaler mouthpiece, was measured experimentally using endoscopic particle image velocimetry (PIV). Measurements were made at three flow rates: 15, 30, and 90 L/min, which correspond to a wide range of physiological conditions. Extensive tests were performed to verify the veracity of the PIV data. The flow was also modeled computationally using Reynolds-averaged Navier–Stokes (RANS) computational fluid dynamics (CFD) methods. The PIV data clearly indicate the complex nature of HOP flow, with three-dimensionality and several regions of separation and recirculation evident. Comparison of the experimental and computational results shows that, although the RANS CFD reproduces the basic features of the flow, it does not adequately capture the increased viscous effects at lower Reynolds numbers. The results demonstrate the need for more development and validation of CFD modeling, in particular RANS methods, in these flows.