Pseudomonas aeruginosa employs a quorum sensing (QS) communication system that
makes use of small diffusible molecules. Among other effects, the QS system coordinates the
formation of biofilm which decisively contributes to difficulties in the therapy of Pseudomonas
infections. The present work deals with the structure-activity exploration of ureidothiophene-
2-carboxylic acids as inhibitors of PqsD, a key enzyme in the biosynthetic pathway of signal
molecules in the Pseudomonas QS system. We describe an improvement of the inhibitory …

P. aeruginosa employs a quorum sensing (QS) communication system that makes use of
small diffusible molecules. Among other effects, the QS system coordinates the formation of
biofilm which decisively contributes to difficulties in the therapy of Pseudomonas infections.
The present work deals with the structureactivity exploration of ureidothiophene-2-carboxylic
acids as inhibitors of PqsD, a key enzyme in the biosynthetic pathway of signal molecules in
the Pseudomonas QS system. We describe an improvement of the inhibitory activity by …