B cells play an essential role in the immune response. Upon activation they may differentiate
into plasma cells that secrete specific antibodies against potentially pathogenic non-self
antigens. To identify the cellular proteins that are important for efficient production of these
antibodies we set out to study the B cell differentiation process at the proteome level. We
performed an in-depth proteomic study to quantify dynamic relative protein expression
patterns of several hundreds of proteins at five consecutive time points after …