Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis
H Habibi, A Suzuki, K Hayashi, H Salimi, Y Hori… - Journal of Orthopaedic …, 2022 - Elsevier
Background Fibrosis is one of the main pathologies caused by hypertrophy of the
ligamentum flavum (LF), which leads to lumbar spinal stenosis (LSS). The fibroblast growth
factor (FGF) family is a key mediator of fibrosis. However, acidic fibroblast growth factor (FGF-
1) expression and function are not well understood in LF. This study sought to evaluate FGF-
1 expression in the hypertrophied and non-hypertrophied human LF, and to investigate its
function using primary human LF cell cultures. Methods We obtained hypertrophied lumbar …
ligamentum flavum (LF), which leads to lumbar spinal stenosis (LSS). The fibroblast growth
factor (FGF) family is a key mediator of fibrosis. However, acidic fibroblast growth factor (FGF-
1) expression and function are not well understood in LF. This study sought to evaluate FGF-
1 expression in the hypertrophied and non-hypertrophied human LF, and to investigate its
function using primary human LF cell cultures. Methods We obtained hypertrophied lumbar …
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