Expression of tetanus toxin fragment C in tobacco chloroplasts

JS Tregoning, P Nixon, H Kuroda, Z Svab… - Nucleic acids …, 2003 - academic.oup.com
tetanus vaccine by expressing the Fragment C domain of the tetanus toxin (TetC) in tobacco
chloroplasts… TetC is a non‐toxic 47 kDa polypeptide fragment shown to induce a protective …

New advances in the production of edible plant vaccines: chloroplast expression of a tetanus vaccine antigen, TetC

J Tregoning, P Maliga, G Dougan, PJ Nixon - Phytochemistry, 2004 - Elsevier
… vaccine based upon the expression of a tetanus antigen, TetC, in the tobaccotetanus toxin
and the TetC fragment. (A) Schematic diagram of the three functional domains of tetanus toxin

Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the …

RE Soria-Guerra, AG Alpuche-Solís… - Planta, 2009 - Springer
… diphtheria toxin, and the C fragment of the tetanus toxin. The … the expression of the DPT
polypeptide in tobacco plants via … to optimize its expression in tobacco chloroplasts. Following …

Co-expression of tetanus toxin fragment C in Escherichia coli with thioredoxin and its evaluation as an effective subunit vaccine candidate

YZ Yu, ZW Gong, Y Ma, SM Zhang, HQ Zhu, WB Wang… - Vaccine, 2011 - Elsevier
fragment C of tetanus toxin has been used as a potential subunit candidate vaccine, recombinant
tetanus toxin fragment C … Furthermore, fragment C of tetanus toxin, more than a carrier, …

Tetanus toxin fragment C: structure, drug discovery research and production

C Bayart, A Mularoni, N Hemmani, S Kerachni, J Jose… - Pharmaceuticals, 2022 - mdpi.com
… were used for recombinant TTFC expression as well as tobacco chloroplasts, representing
a common plant expression system. To obtain satisfying levels of expression in yeast, a …

High‐yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts

A Molina, S Hervás‐Stubbs, H Daniell… - Plant biotechnology …, 2004 - Wiley Online Library
… In the present work, we chose tobacco as the host plant because the chloroplast transformation
method is very efficient. However, the presence of toxic alkaloids in the tobacco plant …

Production of biopharmaceuticals and vaccines in plants via the chloroplast genome

H Daniell - Biotechnology Journal: Healthcare Nutrition …, 2006 - Wiley Online Library
… were expressed in separate tobacco chloroplast transgenic … virulent CPV, was expressed
in tobacco chloroplasts as a fusion … The maximum levels of protein expression were achieved …

Chloroplasts as expression platforms for plant-produced vaccines

T Cardi, P Lenzi, P Maliga - Expert review of vaccines, 2010 - Taylor & Francis
… Tregoning et al. expressed fragment C from tetanus toxin in tobacco chloroplasts at 25% of
the TSP Citation[76]. Three vectors were tested, two with the original AT-rich sequence, and …

High-level expression of tetanus toxin fragment C in Escherichia coli

K Aghaiypour, R Teymourpour - Archives of Razi Institute, 2018 - archrazi.areeo.ac.ir
expressed the rfragment C of tetanus toxin in E. coli regarding the production of recombinant
subunit vaccine against tetanus toxin… and express the fragment C of tetanus toxin, there are …

Generation of plant-derived recombinant DTP subunit vaccine

…, S Spitsin, N Pogrebnyak, K Bandurska, C Portocarrero… - Vaccine, 2009 - Elsevier
… , including the use of tobacco chloroplasts to express the tetanus toxin fragment C (TetC) […
, tetanus toxin fragment C (TetC) and pertussis toxin small subunit (PTX S1) in plant expression