Exquisite ligand stereoselectivity of a Drosophila juvenile hormone receptor contrasts with its broad agonist repertoire
L Bittova, P Jedlicka, M Dracinsky… - Journal of Biological …, 2019 - ASBMB
The sesquiterpenoid juvenile hormone (JH) is vital to insect development and reproduction.
Intracellular JH receptors have recently been established as basic helix-loop-helix
transcription factor (bHLH)/PAS proteins in Drosophila melanogaster known as germ cell–
expressed (Gce) and its duplicate paralog, methoprene-tolerant (Met). Upon binding JH,
Gce/Met activates its target genes. Insects possess multiple native JH homologs whose
molecular activities remain unexplored, and diverse synthetic compounds including …
Intracellular JH receptors have recently been established as basic helix-loop-helix
transcription factor (bHLH)/PAS proteins in Drosophila melanogaster known as germ cell–
expressed (Gce) and its duplicate paralog, methoprene-tolerant (Met). Upon binding JH,
Gce/Met activates its target genes. Insects possess multiple native JH homologs whose
molecular activities remain unexplored, and diverse synthetic compounds including …
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