Extending ITC to Kinetics with kinITC

P Dumas, E Ennifar, C Da Veiga, G Bec, W Palau… - Methods in …, 2016 - Elsevier
Isothermal titration calorimetry (ITC) has long been used for kinetic studies in chemistry, but
this remained confined to enzymatic studies in the biological field. In fact, the biological
community has long had the tendency of ignoring the kinetic possibilities of ITC considering
it solely as a thermodynamic technique, whereas surface plasmon resonance is seen as the
kinetic technique par excellence. However, the primary signal recorded by ITC is a heat
power which is directly related to the kinetics of the reaction. Here, it is shown how this …
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