Extract ethanol of poguntano in alloxan induced diabetic rats
SS Widjaja - Bangladesh Journal of Medical science, 2018 - search.proquest.com
Bangladesh Journal of Medical science, 2018•search.proquest.com
Back Ground: Diabetes mellitus is a group of metabolic disease with high blood glucose
level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty
acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances
that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from
family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant
for treatment of diabetes. Objective: The purpose of this study was to investigate the effect of …
level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty
acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances
that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from
family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant
for treatment of diabetes. Objective: The purpose of this study was to investigate the effect of …
Abstract
Back Ground: Diabetes mellitus is a group of metabolic disease with high blood glucose level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant for treatment of diabetes.
Objective: The purpose of this study was to investigate the effect of extract ethanol of Poguntano in alloxan induced diabetic rats.
Method: Fifteen male Wistar rats with body weight of 150-200 gr were given intra peritoneal injection of 150 mg/kg Alloxan to induce diabetes. These were divided into three groups (control diabetic, group given insulin and group given Extract ethanol of Poguntano 200 mg/Kg body weight) and one control normal control. The duration of study was 4 weeks; blood glucose and Endothelin-1 were measured for all groups.
Results: Extract ethanol of Poguntano 200 mg showed significant results (p< 0.001) in lowering blood glucose in Alloxan induced diabetic rats compared to control diabetic, but did not show superior to insulin group (p= 0.892). Endothelin-1 showed statistical significant between group with normal rats and diabetic control rats.(p= 0.009) but did not in the other groups. Levels of Endothelin-1 was higher in the diabetic control group with the median 1.95 (1, 78-3.1).
Conclusion: In our study we found that extract ethanol of Poguntano showed significant hypoglycemic activity and lowering the Endothelin-1 level in alloxan induced diabetic rats.
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