The gene for pituitary growth hormone (GH-N) in man belongs to a multigene locus located
at chromosome 17q24. 2, which also harbors four additional genes: one for a placental
variant of GH-N (named GH-V) and three of chorionic somatommamotropin (CSH) type.
Their tandem arrangement from 5′ to 3′ is: GH-N, CSH-L, CSH-1, GH-V and CSH-2. GH-
N is mainly expressed in the pituitary from birth throughout life, while the remaining genes
are expressed in the placenta of pregnant women. Pituitary somatotrophs secrete GH into …