FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Abstract Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we
identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1
expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism
independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and
interaction between estrogen receptor-related alpha, flightless-1 (FLII) and leucine-rich …
adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we
identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1
expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism
independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and
interaction between estrogen receptor-related alpha, flightless-1 (FLII) and leucine-rich …
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