FOXO3 transcription factor is essential for protecting hematopoietic stem and progenitor cells from oxidative DNA damage
CL Bigarella, J Li, P Rimmelé, R Liang… - Journal of Biological …, 2017 - ASBMB
Accumulation of damaged DNA in hematopoietic stem cells (HSC) is associated with
chromosomal abnormalities, genomic instability, and HSC aging and might promote
hematological malignancies with age. Despite this, the regulatory pathways implicated in the
HSC DNA damage response have not been fully elucidated. One of the sources of DNA
damage is reactive oxygen species (ROS) generated by both exogenous and endogenous
insults. Balancing ROS levels in HSC requires FOXO3, which is an essential transcription …
chromosomal abnormalities, genomic instability, and HSC aging and might promote
hematological malignancies with age. Despite this, the regulatory pathways implicated in the
HSC DNA damage response have not been fully elucidated. One of the sources of DNA
damage is reactive oxygen species (ROS) generated by both exogenous and endogenous
insults. Balancing ROS levels in HSC requires FOXO3, which is an essential transcription …
以上显示的是最相近的搜索结果。 查看全部搜索结果