Excitability of both stretch reflex (SR) and motor evoked potential (MEP) elicited in the tibialis anterior (TA) muscle by transcranial magnetic stimulation were tested in standing humans. The results demonstrated significantly greater values for both SR and MEP in the TA while standing than while in the supine posture, although background electromyographic activity was silent in the two conditions. Taken together with previous reports that both pathways are facilitated in the TA at the early stance phase of human walking, our findings suggest that a common neural mechanism underlies both observations, one that might be functionally relevant for securing ankle joint stabilization during upright standing.