Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle
T Santalucıa, KR Boheler, NJ Brand, U Sahye… - Journal of Biological …, 1999 - ASBMB
Glucose constitutes a major fuel for the heart, and high glucose uptake during fetal
development is coincident with the highest level of expression of the glucose transporter
GLUT-1 during life. We have previously reported that GLUT-1 is repressed perinatally in rat
heart, and GLUT-4, which shows a low level of expression in the fetal stage, becomes the
main glucose transporter in the adult. Here, we show that the perinatal expression of GLUT-
1 and GLUT-4 glucose transporters in heart is controlled directly at the level of gene …
development is coincident with the highest level of expression of the glucose transporter
GLUT-1 during life. We have previously reported that GLUT-1 is repressed perinatally in rat
heart, and GLUT-4, which shows a low level of expression in the fetal stage, becomes the
main glucose transporter in the adult. Here, we show that the perinatal expression of GLUT-
1 and GLUT-4 glucose transporters in heart is controlled directly at the level of gene …
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