The purpose of this article is to analyze the centrifugal tendencies in 17 Autonomous Communities of Spain by demonstrating that certain differences in the configurations of factors have lead to varying degrees of the loss of autonomy. The main conclusion is that for the configurations leading to less autonomy, there is a low level of economic development, a low volume of EU funding, and an absence of local languages as a factor of identity. The cases of Andalusia, Asturias, and Galicia are of particular importance in these configurations. For the configurations that lead to greater autonomy, two patterns are identified. The first group (Catalonia and the Basque Country) demonstrates a link between centrifugal tendencies and three conditions: the existence of regionalist parties in the parliaments of Autonomous Communities (AC), a high level of economic development and a high level of identification with a regional language. The second group of cases (Valencia and the Canary Islands) demonstrates the added importance of funding under the EU regional policy programs for the period from 2014 to 2020. The scientific novelty of the article lies in its analysis of the dynamics of centrifugal tendencies in Spain via crisp-set Qualitative Comparative Analysis (csQCA).