FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response
R Makowsky, HW Wiener, TS Ptacek… - Pharmacogenetics …, 2013 - journals.lww.com
Objective Kawasaki disease (KD), response to intravenous immunoglobulin (IVIG) therapy,
and associated coronary artery disease progression have been associated with genetic
polymorphisms in Fc gamma receptor (FcγR) genes. However, it is not known whether the
existing gene copy number (GCN) variability relates to KD treatment response, susceptibility,
or associated sequelae. Methods The copy number of individuals with KD (n= 510) and their
family members (n= 808) for three variable FcγRs was assessed using pyrosequencing. We …
and associated coronary artery disease progression have been associated with genetic
polymorphisms in Fc gamma receptor (FcγR) genes. However, it is not known whether the
existing gene copy number (GCN) variability relates to KD treatment response, susceptibility,
or associated sequelae. Methods The copy number of individuals with KD (n= 510) and their
family members (n= 808) for three variable FcγRs was assessed using pyrosequencing. We …
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