Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer
cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of
several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium-and
gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of
these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer
cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of
several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium-and
gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of
these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
Abstract
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果