Fetal–juvenile origins of point mutations in the adult human tracheal–bronchial epithelium: absence of detectable effects of age, gender or smoking status
H Sudo, XC Li-Sucholeiki, LA Marcelino… - Mutation Research …, 2008 - Elsevier
Allele-specific mismatch amplification mutation assays (MAMA) of anatomically distinct
sectors of the upper bronchial tracts of nine nonsmokers revealed many numerically
dispersed clusters of the point mutations C742T, G746T, G747T of the TP53 gene, G35T of
the KRAS gene and G508A of the HPRT1 gene. Assays of these five mutations in six
smokers have yielded quantitatively similar results. One hundred and eighty four micro-
anatomical sectors of 0.5–6× 106 tracheal–bronchial epithelial cells represented en toto the …
sectors of the upper bronchial tracts of nine nonsmokers revealed many numerically
dispersed clusters of the point mutations C742T, G746T, G747T of the TP53 gene, G35T of
the KRAS gene and G508A of the HPRT1 gene. Assays of these five mutations in six
smokers have yielded quantitatively similar results. One hundred and eighty four micro-
anatomical sectors of 0.5–6× 106 tracheal–bronchial epithelial cells represented en toto the …
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