Fibrotic venous remodeling and nonmaturation of arteriovenous fistulas

L Martinez, JC Duque, M Tabbara, A Paez… - Journal of the …, 2018 - journals.lww.com
The frequency of primary failure in arteriovenous fistulas (AVFs) remains unacceptably high.
This lack of improvement is due in part to a poor understanding of the pathobiology
underlying AVF nonmaturation. This observational study quantified the progression of three
vascular features, medial fibrosis, intimal hyperplasia (IH), and collagen fiber organization,
during early AVF remodeling and evaluated the associations thereof with AVF
nonmaturation. We obtained venous samples from patients undergoing two-stage upper …
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