A Field experiment was conducted at Ardokola (8°89′N and 11°37′E) and Gassol (8°39′N and 10°47′N) in 2011 to investigate the effectiveness of five plant extracts (Azadirachta indica, Jatropha curcas Linn., Alium sativum, Ocimum gratissimum (L.), Chromolaena odorata and Benomyl) in the control of CLS disease caused by Cercospora sesami on four selected sesame varieties. The trial was designed using Randomized Complete Block Design (RCBD) in allocating treatments including the control to plots which was replicated four times. In both locations sesame plants were sprayed with 10% extracts once in every two weeks using ULV sprayer from 4 to 10 weeks after sowing. Results obtained for the two locations showed that all the extracts reduced the amount of disease by 7.1% to 8.64% compared to unsprayed plot (with severity range of 55% to 58%). Similarly, plant extracts gave 40.71% and 38.22% increase in yield over the unsprayed plots (548.66 and 551.04 kgha^-1) for Ardokola and Gassol respectively. The variations in disease intensity obtained with various plant extracts were negatively correlated with the seed yield, hence the observed differences in yields were attributable to the CLS disease intensity.