Type 2 diabetes (T2D) is a disease of relative insulin deficiency resulting from both insulin
resistance and beta cell failure. We have previously used heterogeneous stock (HS) rats to
fine-map a locus for glucose tolerance. We show here that glucose intolerance in the
founder strains of the HS colony is mediated by different mechanisms: insulin resistance in
WKY and an insulin secretion defect in ACI, and we demonstrate a high degree of variability
for measures of insulin resistance and insulin secretion in HS rats. As such, our goal was to …

Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock
rats. Physiol Genomics 44: 1013–1026, 2012. First published September 4, 2012; doi:
10.1152/physiolgenomics. 00040.2012.—Type 2 diabetes (T2D) is a disease of relative
insulin deficiency resulting from both insulin resistance and beta cell failure. We have
previously used heterogeneous stock (HS) rats to fine-map a locus for glucose tolerance.
We show here that glucose intolerance in the founder strains of the HS colony is mediated …