Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis
Multiple sclerosis is a demyelinating disease affecting the central nervous system. T cells
are known to contribute to this immune-mediated condition. Fingolimod modulates
sphingosine-1-phosphate receptors, thereby preventing the egress of lymphocytes,
especially CCR7-expressing CD8+ and CD4+ T cells, from lymphoid tissues. Using
Affymetrix Human Transcriptome Arrays (HTA 2.0), we performed a transcriptome profiling
analysis of CD4+ cells obtained from the peripheral blood of patients with highly active …
are known to contribute to this immune-mediated condition. Fingolimod modulates
sphingosine-1-phosphate receptors, thereby preventing the egress of lymphocytes,
especially CCR7-expressing CD8+ and CD4+ T cells, from lymphoid tissues. Using
Affymetrix Human Transcriptome Arrays (HTA 2.0), we performed a transcriptome profiling
analysis of CD4+ cells obtained from the peripheral blood of patients with highly active …
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