Scleral thickness, especially near the optic nerve head (ONH), is a potential factor of interest
in the development of glaucomatous optic neuropathy. Large differences in the dimensions
of the sclera, the principal load-bearing tissue of the eye, have been observed between
individuals. This study aimed to characterize the effects of these differences on ONH
biomechanics. Eleven enucleated human globes (7 normal and 4 ostensibly glaucomatous)
were imaged using high-field microMRI and segmented to produce 3-D individual-specific …