The existing data of antinucleon-nucleon and antinucleon-nuclei annihilation cross-sections are confined to energies above about 1MeV. Experimental limitations have prevented till now the lower energies data to be achieved in spite of the interest they represent for theoretical models. One of the unresolved question concerns the antiproton annihilation cross-section measured at LEAR on light nuclei in the MeV region, which show a saturation with the mass number of the target nucleus against any naive expectation. With regard to fundamental cosmology, the knowledge of the annihilation cross-sections at energies below 1MeV can contribute to understand the matter-antimatter asymmetry in the Universe. We present here the experimental demonstration of the feasibility of the measurement of antiproton-nuclei annihilation cross-sections in the 100 keV region.