Flavonoid-rich extract of Chromolaena odorata modulate circulating GLP-1 in Wistar rats: computational evaluation of TGR5 involvement
Chromolaena odorata is a major bio-resource in folkloric treatment of diabetes. In the
present study, its anti-diabetic component and underlying mechanism were investigated. A
library containing 140 phytocompounds previously characterized from C. odorata was
generated and docked (Autodock Vina) into homology models of dipeptidyl peptidase (DPP)-
4, Takeda-G-protein-receptor-5 (TGR5), glucagon-like peptide 1 (GLP1) receptor, renal
sodium dependent glucose transporter (SGLUT)-1/2 and nucleotide-binding oligomerization …
present study, its anti-diabetic component and underlying mechanism were investigated. A
library containing 140 phytocompounds previously characterized from C. odorata was
generated and docked (Autodock Vina) into homology models of dipeptidyl peptidase (DPP)-
4, Takeda-G-protein-receptor-5 (TGR5), glucagon-like peptide 1 (GLP1) receptor, renal
sodium dependent glucose transporter (SGLUT)-1/2 and nucleotide-binding oligomerization …
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