Flexible routing of motor control signals through neocortical projection neuron classes
Motor cortex is a key node in the forebrain circuits that enable flexible control of limb
movements. The influence of motor cortex on movement execution is primarily carried by
either pyramidal tract (PT) neurons, which project directly to the midbrain, brainstem and
spinal cord, or intratelencephalic (IT) neurons, which project within the forebrain. The logic of
the interplay between these cell types and their relative contribution to the control of forelimb
movements remains unclear. Here we combine large-scale neural recordings across all …
movements. The influence of motor cortex on movement execution is primarily carried by
either pyramidal tract (PT) neurons, which project directly to the midbrain, brainstem and
spinal cord, or intratelencephalic (IT) neurons, which project within the forebrain. The logic of
the interplay between these cell types and their relative contribution to the control of forelimb
movements remains unclear. Here we combine large-scale neural recordings across all …
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