Floods are among the most devastating natural hazards in society. Flood forecasting is crucially important in order to provide warnings in time to protect people and properties from such disasters. This research applied the high-resolution coupled hydrologic–hydraulic model from the University of California, Irvine, named HiResFlood-UCI, to simulate the historical 2008 Iowa flood. HiResFlood-UCI was forced with the near-real-time Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks–Cloud Classification System (PERSIANN-CCS) and NEXRAD Stage 2 precipitation data. The model was run using the a priori hydrologic parameters and hydraulic Manning n values from lookup tables. The model results were evaluated in two aspects: point comparison using USGS streamflow and areal validation of inundation maps using USDA’s flood extent maps derived from Advanced Wide Field Sensor (AWiFS) 56-m resolution imagery. The results show that the PERSIANN-CCS simulation tends to capture the observed hydrograph shape better than Stage 2 (minimum correlation of 0.86 for PERSIANN-CCS and 0.72 for Stage 2); however, at most of the stream gauges, Stage 2 simulation provides more accurate estimates of flood peaks compared to PERSIANN-CCS (49%–90% bias reduction from PERSIANN-CCS to Stage 2). The simulation in both cases shows a good agreement (0.67 and 0.73 critical success index for Stage 2 and PERSIANN-CCS simulations, respectively) with the AWiFS flood extent. Since the PERSIANN-CCS simulation slightly underestimated the discharge, the probability of detection (0.93) is slightly lower than that of the Stage 2 simulation (0.97). As a trade-off, the false alarm rate for the PERSIANN-CCS simulation (0.23) is better than that of the Stage 2 simulation (0.31).