This paper couples an adaptive neuro-fuzzy inference system (ANFIS), with two heuristic-based computation methods namely biogeography-based optimization (BBO) and BAT algorithm (BA) with GIS to map flood susceptibility in a region of Iran. These algorithms have been used for flood modelling, infrequently. A total of 287 flood locations were randomly categorized into training (70%; 201 floods), and validation (30%; 86 floods) datasets for modelling process and evaluation. The Step-wise Weight Assessment Ratio Analysis (SWARA) technique was applied to evaluate the role of nine dominant factors on flood occurrence. The results of using the ANFIS and the artificial intelligence ensemble algorithms were three flood susceptibility maps. Results indicated that the ANFIS-BBO had the highest accuracy in comparison with the ANFIS and ANFIS-BA models in flood modelling. In addition, BBO algorithm showed its great potential by considering higher accuracy and lower computational time, in mapping and assessment of flood susceptibility.