Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure
JR Hutson, B Stade, DC Lehotay, CP Collier… - PloS one, 2012 - journals.plos.org
JR Hutson, B Stade, DC Lehotay, CP Collier, BM Kapur
PloS one, 2012•journals.plos.orgBackground During pregnancy, the demand for folic acid increases since the fetus requires
this nutrient for its rapid growth and cell proliferation. The placenta concentrates folic acid
into the fetal circulation; as a result the fetal levels are 2 to 4 times higher than the maternal
level. Animal and in vitro studies have suggested that alcohol may impair transport of folic
acid across the placenta by decreasing expression of transport proteins. We aim to
determine if folate transfer to the fetus is altered in human pregnancies with chronic alcohol …
this nutrient for its rapid growth and cell proliferation. The placenta concentrates folic acid
into the fetal circulation; as a result the fetal levels are 2 to 4 times higher than the maternal
level. Animal and in vitro studies have suggested that alcohol may impair transport of folic
acid across the placenta by decreasing expression of transport proteins. We aim to
determine if folate transfer to the fetus is altered in human pregnancies with chronic alcohol …
Background
During pregnancy, the demand for folic acid increases since the fetus requires this nutrient for its rapid growth and cell proliferation. The placenta concentrates folic acid into the fetal circulation; as a result the fetal levels are 2 to 4 times higher than the maternal level. Animal and in vitro studies have suggested that alcohol may impair transport of folic acid across the placenta by decreasing expression of transport proteins. We aim to determine if folate transfer to the fetus is altered in human pregnancies with chronic alcohol consumption.
Methodology/Principal Findings
Serum folate was measured in maternal blood and umbilical cord blood at the time of delivery in pregnancies with chronic and heavy alcohol exposure (n = 23) and in non-drinking controls (n = 24). In the alcohol-exposed pairs, the fetal∶maternal serum folate ratio was ≤1.0 in over half (n = 14), whereas all but one of the controls were >1.0. Mean folate in cord samples was lower in the alcohol-exposed group than in the controls (33.15±19.89 vs 45.91±20.73, p = 0.04).
Conclusions/Significance
Our results demonstrate that chronic and heavy alcohol use in pregnancy impairs folate transport to the fetus. Altered folate concentrations within the placenta and in the fetus may in part contribute to the deficits observed in the fetal alcohol spectrum disorders.
PLOS以上显示的是最相近的搜索结果。 查看全部搜索结果