Forces for morphogenesis investigated with laser microsurgery and quantitative modeling
MS Hutson, Y Tokutake, MS Chang, JW Bloor… - Science, 2003 - science.org
We investigated the forces that connect the genetic program of development to
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for
development and wound healing. We found that the bulk of progress toward closure is
driven by contractility in supracellular “purse strings” and in the amnioserosa, whereas
adhesion-mediated zipping coordinates the forces produced by the purse strings and is
essential only for the end stages. We applied quantitative modeling to show that these …
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for
development and wound healing. We found that the bulk of progress toward closure is
driven by contractility in supracellular “purse strings” and in the amnioserosa, whereas
adhesion-mediated zipping coordinates the forces produced by the purse strings and is
essential only for the end stages. We applied quantitative modeling to show that these …
Forces for morphogenesis investigated with laser microsurgery and quantitative modelling
JW Bloor - Science, 2003 - kar.kent.ac.uk
We investigated the forces that connect the genetic program of development to
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for
development and wound healing. We found that the bulk of progress toward closure is
driven by contractility in supracellular" purse strings" and in the amnioserosa, whereas
adhesion-mediated zipping coordinates the forces produced by the purse strings and is
essential only for the end stages. We applied quantitative modeling to show that these …
morphogenesis in Drosophila. We focused on dorsal closure, a powerful model system for
development and wound healing. We found that the bulk of progress toward closure is
driven by contractility in supracellular" purse strings" and in the amnioserosa, whereas
adhesion-mediated zipping coordinates the forces produced by the purse strings and is
essential only for the end stages. We applied quantitative modeling to show that these …
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