Media formulation optimization: current and future opportunities

SC Galbraith, H Bhatia, H Liu, S Yoon - Current opinion in chemical …, 2018 - Elsevier
… used to optimize media formulations as well … formulation optimization is a critical part of
process development. The decision on which strategy to use for media formulation optimization

Optimization techniques in pharmaceutical formulation and processing

JB Schwartz, RE O'Connor… - Modern pharmaceutics, 2002 - taylorfrancis.com
… for a given product, one qualitatively selects a formulation. It is at this point that optimization
can become a useful tool to quantitate a formulation that has been qualitatively determined. …

[PDF][PDF] Optimization techniques: an overview for formulation development

RK Garg, I Singhvi - Asian J. Pharm. Res. Vol, 2015 - ajprjournal.com
Optimization is defined as follows: “Choosing the best element … formulation is achieved
by various Optimization techniques like DoE (Design of Experiment). The term FbD (Formulation

[HTML][HTML] Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery

J Malakar, SO Sen, AK Nayak, KK Sen - Saudi pharmaceutical journal, 2012 - Elsevier
… develop and optimizeoptimized transferosomal gel by iontophoresis for further insulin
permeation improvement. Finally, we have performed a short-term in vivo evaluation of optimized

Problem formulation for multidisciplinary optimization

EJ Cramer, JE Dennis, Jr, PD Frank, RM Lewis… - … Journal on Optimization, 1994 - SIAM
… If we apply a feasibility restoration method to an AAO formulation, then at each optimization
iteration the optimization algorithm would first take a step in the full space to obtain a …

Formulation, optimization and application of triglyceride microemulsion in enhanced oil recovery

Z Jeirani, BM Jan, BS Ali, IM Noor, CH See… - Industrial crops and …, 2013 - Elsevier
This paper presents the determination of an aqueous phase composition of a new
triglyceride microemulsion in which the triglycerides constitute the whole oil-phase of the …

Neural network based optimization of drug formulations

K Takayama, M Fujikawa, Y Obata… - Advanced drug delivery …, 2003 - Elsevier
… (3) multi-objective optimization for seeking the best formulation under a set of pragmatic
constraints… rationale model formulations, which are composed of several formulation factors and …

Formulation optimization of controlled release diclofenac sodium microspheres using factorial design

MC Gohel, AF Amin - Journal of controlled release, 1998 - Elsevier
formulation in shortest possible time using minimum number of man hours and raw materials.
In addition to the art of formulation, … , was adopted to optimize microspheres of model drug …

Chemical denaturation as a tool in the formulation optimization of biologics

E Freire, A Schön, BM Hutchins, RK Brown - Drug discovery today, 2013 - Elsevier
… In this review, we will discuss chemical denaturation as a tool in the optimization of formulation
conditions for biologics, and how chemical denaturation complements the role of thermal …

Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery

Y Onuki, M Morishita, K Takayama - Journal of controlled Release, 2004 - Elsevier
… The objective of this study was to optimize formulation of the multiple emulsion for mucosal
insulin delivery. First, the causal factors' influence on individual characteristics of the emulsion…