[PDF][PDF] Formulation and evaluation of in vitro transdermal patch diclofenac sodium using chitosan polymer and polyvinyl alcohol cross-linked tripolyphosphate Sodium
ABSTRACT Materials and Methods: The chemical characterization of diclofenac sodium was
done by ultraviolet-visible spectrophotometry. Formulation of diclofenac sodium patches
using solvent evaporation method with cross-link technique. Evaluation of physical character
of the film includes organoleptic observation, weight test, thickness,% moisture absorption,
fold resistance, interaction between materials used Fourier transform infrared (FTIR), and
active substance levels. The drug release was determined using Franz diffusion cells in …
done by ultraviolet-visible spectrophotometry. Formulation of diclofenac sodium patches
using solvent evaporation method with cross-link technique. Evaluation of physical character
of the film includes organoleptic observation, weight test, thickness,% moisture absorption,
fold resistance, interaction between materials used Fourier transform infrared (FTIR), and
active substance levels. The drug release was determined using Franz diffusion cells in …
Abstract
Materials and Methods: The chemical characterization of diclofenac sodium was done by ultraviolet-visible spectrophotometry. Formulation of diclofenac sodium patches using solvent evaporation method with cross-link technique. Evaluation of physical character of the film includes organoleptic observation, weight test, thickness,% moisture absorption, fold resistance, interaction between materials used Fourier transform infrared (FTIR), and active substance levels. The drug release was determined using Franz diffusion cells in phosphate buffer (pH 7.4).
Conclusion: The diclofenac sodium can be prepared by cross-linked method, resulted in a better discharge profile.
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