Alopecia is one of the common causes of hair loss in the world. Aimed to improve drug
delivery to hair follicles, a box benken design was applied to formulate minoxidil and
caffeine in liposomes with flexible membrane (transfersome). The ratio of polysorbate 20
and polysorbate 80, as the edge activators, and the hydration volume were studied as
independent variables. Furthermore, entrapment efficiency, release rate, and stability of
transfersomes were evaluated as dependent variables. The results showed that using of …